Useful Info
THE MISFITS   


Neurologic emergencies
Recognizing a neurologic insult in neonates may be difficult. The clinical
symptoms may be nonspecific. The history may reveal only a change in feeding
pattern or subtle behavioral changes. A useful mnemonic to recall the broad
differential diagnosis of a neonate with altered mental status, ‘‘THE MISFITS,’’
is outlined in Box  Keeping this mnemonic in mind as well as a high index of
suspicion during the initial history and physical examination (non) will help
guide the evaluation and management
 
 Causes of altered mental status in a neonate: THE MISFITS

T–Trauma (nonaccidental and accidental)
H–Heart disease and hypovolemia
E–Endocrine (eg, congenital adrenal hyperplasia and thyrotoxicosis)
M–Metabolic (electrolyte imbalance)
I–Inborn errors of metabolism
S–Sepsis (eg, meningitis, pneumonia, and urinary tract infection)
F–Formula mishaps (eg, under- or overdilution)
I–Intestinal catastrophes (eg, volvulus, intussusception, and necrotizing enterocolitis)
T–Toxins and poisons
S–Seizures

 Source= http://hsc.unm.edu/emermed/ped/physicians/residents/articles/Newborn%20Emergencies%20The%20First%2030%20Days%20of%20Life.pdf
Body regulates thousands of metabolic reactions simultaneously    

Our body get the energy they need from food through metabolism, the chemical reactions in the body cellls that convert the fuel from food into the energy needed to do everything from moving to thinking to growing. Specific proteins in the body control the chemical reactions of metabolism, and each chemical reaction is coordinated with other body functions. In fact, thousands of metabolic reactions happen at the same time — all regulated by the body — to keep our cells healthy and working.

Metabolism is a constant process that begins when we are conceived and ends when we die. It is a vital process for all life forms — not just humans. If metabolism stops, a living thing dies.

Here an example of how the process of metabolism works in humans — and it begins with plants. First, a green plant takes in energy from sunlight. The plant uses this energy and the molecule cholorophyll (which gives plants their green color) to build sugars from water and carbon dioxide in a process known as photosynthesis.

When people and animals eat the plants (or, if they are carnivores, when they eat animals that have eaten the plants), they take in this energy (in the form of sugar), along with other vital cell-building chemicals. The body next step is to break the sugar down so that the energy released can be distributed to, and used as fuel by, the body cells

  source=http://kidshealth.org/

Dr Archibald Edward Garrod

Gene&Gene Mutation

Metabolic Acidosis

Unusual Smell In Urine?

The Role of Neuroimaging in Diagnosis and Treatment of inborn errors of metabolism

During Gestation

Did You know?

Can you believe?

Blood Gases

What Is Cell ?

Proteins

Metabolic Pathways

ESSENTIAL / NONESSENTIL AMINO ACIDS

Few UseFul Marker In IEM

Pyruvate Metabolism

GENETIC COUNSELLING

REVIEW(IEM)

Over the last 3 decades many new and effective therapies.....

Essential role of medical food for IEM

"Criterion for including a test in NBS Panel"

Current Treatment Strategies(IEM)

Benefit of newborn screening

Robert Guthrie

Inborn Errors of Metabolism in Infancy: A Guide to Diagnosis

Metabolism Summary

Valid XHTML 1.0 Transitional Valid CSS!