There are a number of strategies available to treat inherited metabolic diseases and these are often related to whether the clinical symptoms are caused by accumulation or depletion.

 

 

1. Reducing Substrate Accumulation by manipulation of diet, chelationor inhibition of biosynthesis.

 

 

2. Reducing toxic metabolites by decreasing production, facilitating transport or promoting excretion

 

 

3. Enhancing residual activity by supraphysiologicaldoses of cofactors and their precursors

 

 

4. Replacement of the defective enzyme by the administration of exogenous enzyme (Enzyme Replacement Therapy, ERT) or by transplantation.

 

 

5. Supplementation of a depleted metabolite by diet or by medication.

 

 

source.http://www.metbio.net/docs/MetBio-TrainingDoc-HAHU926635-17-08-2010.pdf